RECORD NUMBER: 107-250391

CHEMICAL NAME: FLUPROPANATE, TETRAPION (Frenock)

                          Sodium 2,2,3,3-tetra fluoropropinate

CAS REGISTRY NUMBER:            22898-01-7

CHEMICAL FAMILY:                Not available

MOLECULAR FORMULAE:

DESCRIPTION: Pale amber liquid, soluble in water, ethanol, methanol and acetone. Insoluble in most other organic solvents.

USAGE: Frenock (formulated product) is an organic compound used as a selective translocated herbicide for the control of Parrammatta Grass.(2) It is Schedule 6 poison.

 Agricultural -  Herbicide

 Industrial   -

 Domestic     -

TOLERANCE & EXPOSURE LEVELS: Acceptable Daily Intake: 0.0025 mg/kg

HEALTH EFFECTS:

SHORT TERM: Short term exposure by all routes is considered harmful.

                Skin and eye contact may result in mild irritation.

                Inhalation can produce respiratory irritation.

                Ingestion may cause sluggishness and diarrhoea.  (1)

LONG TERM: Prolonged skin contact may lead to dermatitis effects and may lead to absorption through the skin with resultant   toxic effects.   (1) No long term studies carried out other than 90 day feeding study. (6)

CARCINOGENICITY: No data available.

MUTAGENICITY:   Animal tests indicate it is not mutagenic. (1)

REPRODUCTIVE EFFECTS:

BIO-ACCUMULATION: No data available.

Suspected Effects:

ANIMAL TOXICITY DATA:    Oral Rat      LD 50: >8000mg/kg

                        Dermal Rabbit   LD 50: >4000mg/kg (1)

              NOEL (rat) is 100ppm or 5mg/kg in a 90 day feeding study.(1)

      * No long term studies carried out other than a 90 day feeding study.

CARCINOGENICITY:   No data available.

MUTAGENICITY:   Negative in IN VITRO mutagenicity assays.  (1)

REPRODUCTIVE EFFECTS:Manufacturers state that Frenock is negative in teratogenic tests in rats at dose levels up to            100mg/kg (1)

BIO-ACCUMULATION:    Withholding period for stock is 14 days for spot spraying and 4 months for blanket spraying of  Frenock.(5)   No other data available.

Wildlife Data:      Low toxicity to fish.(1)

ENVIRONMENTAL EFFECTS:

Environmental Fate: Very slow rate of biodegradation. (1) Frenock is residual to some extent in soil and plant tissue. It is removed by leaching  and broken down rapidly under anaerobic conditions in subsoil.

Frenock has a long lifespan in plant tissue and persists in susceptible species until plant dies and decays. (5)

Water MRL:  No MRL set.

EPA DATA GAPS:

NOTES: Lactating dairy cows or goats must not be grazed on Frenock treated areas as no MRL has been set for Frenock in milk.  (5) No further testing including chronic studies will be carried out and no MRL for milk will be assigned as chemical usage will remain for non-food use.(6)

** Disclaimer: These sheets are designed as summary information and as such are a guide only.

References:

1. ICI Data Sheet 11.89

2. Agricultural Chemicals, Book 4 Fungicides 1982-83 Revision WT Thomson.

3. Correspondence ICI Mr Alan Jacques. 6 Aug 1986

4. Correspondence ICI Mr Susan Taplin. 27 June 1988

5. Comparative Analysis of Frenock and 2,2-DPA. NSW Dept of Agriculture &

   Fisheries.

6. Pers. Communication: Mr Don Mathews ICI, 12.2.91